Introduction
Cortisone side effects are something many patients worry about when considering this popular treatment for pain and inflammation. While cortisone shots can offer significant relief, it’s important to be well-informed about the potential downsides. Here are some common cortisone side effects you should be aware of:
- Dizziness
- Headaches
- Skin issues
- Fatigue
- Trouble sleeping
Cortisone shots are used to relieve pain and reduce inflammation in various parts of the body such as the knees, shoulders, and wrists. At Boston Concierge Orthopedics, we understand the importance of balancing effective treatment with manageable side effects. Whether you’re an athlete dealing with chronic pain or someone looking to enhance their mobility, understanding both the benefits and risks of cortisone shots is crucial.
My name is Robert McLaughlin II, MD, and I have over 25 years of experience in orthopedic surgery. I’ve seen how cortisone side effects can impact patients, and my aim is to help you make an informed decision about your treatment options.

Common Side Effects of Cortisone Shots
Even though cortisone shots can bring significant relief, they come with some common side effects. Here’s what you need to know:
Skin Issues
Cortisone shots can cause a variety of skin problems. Dryness, thinness, and acne are some of the most common issues. You might also notice red blotches or areas of hypopigmentation (pale skin) where the shot was given.
Dryness and Thinness: The skin around the injection site might become dry and thin. This happens because cortisone can affect the underlying skin structure.
Acne and Red Blotches: Some people develop acne or red blotches after receiving a cortisone shot. This is usually temporary but can be bothersome.
Dr. Halim from the Cleveland Clinic notes that these skin changes are generally temporary but can be a nuisance for many patients.
Fatigue and Trouble Sleeping
Fatigue and trouble sleeping are also common side effects. These can affect your daily life and overall well-being.
Insomnia: Cortisone can cause insomnia, making it hard to fall asleep or stay asleep. This can lead to tiredness and lethargy during the day. Practicing good sleep hygiene can help manage these symptoms.
Lethargy and Tiredness: Feeling unusually tired or lethargic is another common side effect. This can be due to the body’s response to the cortisone or the lack of restful sleep.

If you experience severe or persistent side effects, consult your healthcare provider. They can help you manage these symptoms and adjust your treatment plan if necessary.
Next, let’s delve into more serious side effects like cartilage damage and bone death.
Serious Side Effects of Cortisone Shots
While cortisone shots can be a game-changer for pain relief, they come with their share of serious side effects. Here’s what you need to know about the potential risks.
Cartilage Damage and Bone Death
Cartilage Damage: Repeated cortisone injections can weaken the cartilage in your joints. Over time, this can lead to a reduced cushion between bones, increasing the risk of arthritis. Research indicates that frequent injections may harm cartilage, causing it to wear down faster than it naturally would.
Bone Death (Osteonecrosis): Although rare, cortisone shots can lead to osteonecrosis or bone death. This occurs when the blood supply to a bone is reduced, causing the bone tissue to die. Symptoms include joint pain and decreased range of motion. If you experience these symptoms, consult your healthcare provider immediately.
Joint Infection and Nerve Damage
Joint Infection: One of the more serious risks of cortisone shots is infection at the injection site. Even with sterile techniques, there’s a small chance bacteria can enter the joint, leading to severe complications. Signs of infection include increasing pain, redness, and swelling lasting more than 48 hours. If you notice these symptoms, seek medical attention right away.
Nerve Damage: Cortisone injections can sometimes cause nerve damage, especially if administered improperly. This can result in numbness, tingling, or even long-term nerve injury. According to experts, using ultrasound to guide the needle can minimize this risk, but it’s still a potential side effect.
Tendon Weakening and Rupture
Tendon Weakening: Cortisone can weaken tendons, making them more prone to tears or ruptures. This is particularly concerning for weight-bearing tendons like the Achilles tendon. If you’ve had multiple injections in the same area, you may notice decreased stability or strength over time.
Tendon Rupture: In severe cases, weakened tendons can rupture, causing intense pain and functional impairment. For instance, athletes who receive frequent cortisone shots in their elbows for tennis elbow may face a sudden tendon rupture during a game. Always follow your healthcare provider’s guidelines on the frequency and location of injections to avoid this risk.
Osteoporosis
Bone Thinning: Long-term use of cortisone can lead to osteoporosis, a condition where bones become weak and brittle. This is especially true if you’re receiving systemic corticosteroids. To counteract this, your healthcare provider might recommend calcium and vitamin D supplements to help maintain bone health.
Fracture Risk: With weakened bones, the risk of fractures increases. If you have a history of osteoporosis or are at risk, discuss this with your provider before starting cortisone injections.
Understanding these serious side effects can help you make informed decisions about your treatment. Always discuss the risks and benefits with your healthcare provider to ensure the best outcome for your health.
Next, let’s look at some short-term side effects like facial flushing and pain flare.
Short-Term Side Effects
Facial Flushing and Pain Flare
Facial flushing can happen after a cortisone shot. This means your face might turn red and feel warm. It’s usually harmless and goes away on its own. For some people, it can be a bit embarrassing, but it’s temporary and not painful.
Pain flare is another common short-term side effect. Right after the injection, you might feel more pain at the injection site. This is called a “post-injection flare.” It usually lasts for 24 to 48 hours. Using an ice pack can help reduce the pain and swelling. Avoid using heating pads as they can make it worse.
Blood Sugar Increase
Cortisone shots can cause a temporary spike in blood sugar levels. This is especially important for people with diabetes. After the shot, monitor your blood sugar more closely. This spike usually lasts about a week.
If you have diabetes, talk to your healthcare provider. They might adjust your diabetes medication temporarily to help manage this side effect.
Key Points:
– Facial flushing and pain flare are common but temporary.
– Blood sugar spikes can happen, especially in people with diabetes.
– Use ice packs for pain relief and monitor blood sugar levels closely.
Understanding these short-term side effects can help you prepare and manage them effectively. Next, we’ll dive into some long-term side effects like weight gain and high blood pressure.
Long-Term Side Effects
Weight Gain and High Blood Pressure
One of the notable long-term cortisone side effects is weight gain. This usually happens due to increased appetite and fluid retention. Corticosteroids can make you feel hungrier, leading to overeating. They also cause your body to retain more sodium, which in turn holds onto water, making you feel bloated.
High blood pressure is another concern. The extra fluid in your body puts more pressure on your blood vessels. Over time, this can lead to hypertension. If you’re already dealing with blood pressure issues, be sure to talk to your healthcare provider. They might adjust your medication to help manage this side effect.
Key Points:
– Weight Gain: Often due to increased appetite and fluid retention.
– High Blood Pressure: Caused by extra fluid putting pressure on blood vessels.
– Management: Monitor your weight and blood pressure regularly. Discuss any changes with your healthcare provider.
Mood Changes and Psychological Effects
Corticosteroids can also affect your mood. Some people experience mood swings, ranging from extreme happiness to irritability. Depression and anxiety are also possible. These mood changes can be tough to handle, especially if you’re already dealing with a chronic condition.
Case Study: Dr. Revital Gorodeski Baskin, an endocrinology and diabetes specialist, noted that high doses of steroids could cause psychological distress, poor sleep, paranoid thoughts, and anxiety. This is something to be aware of if you’re on long-term cortisone therapy.
Key Points:
– Mood Swings: Can range from extreme happiness to irritability.
– Depression and Anxiety: Possible with long-term use.
– Management: Communicate any mood changes to your healthcare provider. They may adjust your treatment plan or offer additional support.
Understanding these long-term side effects can help you manage them better. Next, we’ll answer some frequently asked questions about cortisone side effects.
Frequently Asked Questions about Cortisone Side Effects
Do cortisone shots make you tired?
Yes, cortisone shots can make you feel tired. Fatigue is a common side effect, especially in the days following the injection. This is due to the body’s response to the corticosteroid. Some people experience lethargy and a general feeling of tiredness.
Example: Imagine getting a cortisone shot in your knee. You might feel a burst of energy initially, but by the next day, you could feel unusually sleepy or fatigued. This is normal and should pass within a few days.
How long do cortisone shot side effects last?
Cortisone shot side effects can vary in duration. Short-term side effects like facial flushing, pain flare, and blood sugar spikes usually last for a few days. For instance, you might experience a temporary increase in pain at the injection site, known as a “cortisone flare,” which can last up to 48 hours.
Long-term side effects depend on the dose and frequency of injections. These can include weight gain, high blood pressure, and mood changes. If you receive frequent injections, you might also face more severe issues like thinning of the skin or osteoporosis.
Key Points:
– Short-Term: Effects like pain flare and facial flushing last a few days.
– Long-Term: Issues like weight gain and high blood pressure develop over time.
What are the worst side effects of cortisone injections?
The most serious side effects of cortisone injections include cartilage damage and bone death (avascular necrosis). Repeated injections can weaken tendons and even cause them to rupture.
Example: If you receive multiple cortisone shots in your shoulder, you might experience tendon weakening, making it more susceptible to tears during activities.
Key Points:
– Cartilage Damage: Can lead to joint problems over time.
– Bone Death: Avascular necrosis is rare but serious.
– Tendon Weakening: Multiple injections can increase the risk of tendon rupture.
Understanding these potential cortisone side effects can help you make informed decisions about your treatment. Always discuss any concerns with your healthcare provider to manage risks effectively.
Conclusion
At Boston Concierge Orthopedics, we understand that managing pain and inflammation is crucial to improving your quality of life. Our team is dedicated to providing personalized care that addresses your unique needs.
While cortisone shots can offer significant relief, be aware of the potential side effects. Our experts are here to guide you through the process, ensuring you make informed decisions about your treatment options.
Improved Mobility
Our goal is to help you regain mobility and live a pain-free life. By carefully considering your medical history and current condition, we tailor treatments that offer the best outcomes.
High-Quality Treatment
We pride ourselves on delivering high-quality care. From the initial consultation to the follow-up appointments, we focus on your well-being and long-term health.
If you’re ready to explore how cortisone shots can help you, book an appointment with our pain management physicians. Our team is here to support you every step of the way.